Platelet-rich plasma: clinical applications in dentistry.
نویسندگان
چکیده
BACKGROUND Platelet-rich plasma, or PRP, has become a valuable adjunct in wound healing in dentistry. Postsurgically, blood clots initiate the healing and regeneration of hard and soft tissues. Clinicians and scientists are investigating the use of PRP in dentistry as a way to enhance the body's natural wound-healing mechanisms. TYPES OF ARTICLES REVIEWED: The authors reviewed scientific articles that discuss the basic knowledge of wound healing mechanisms and that directly studied the growth factors shown to be concentrated in PRP. They also reviewed articles written by clinicians and researchers in dentistry fields, including oral and maxillofacial surgery and periodontics to determine applications of PRP in the field of dentistry. RESULTS All of the reviewed articles expressed promise in PRP use and in the growth factors expressed by the platelets concentrated in PRP-namely platelet-derived growth factor, or PDGF, and transforming growth factor-beta, or TGF-beta--as an adjunct to postsurgical wound healing. Both PDGF and TGF-beta have been shown in vivo to accelerate wound healing through different mechanisms. The development of an autologous PRP has been shown to be relatively easy, to be effective as a surgical adjunct, to retain high levels of the desired growth factors after preparation and to be clinically effective in accelerating postsurgical healing in both periodontal and oral surgery applications. CLINICAL IMPLICATIONS PRP has proven to be effective at improving surgical results in a variety of procedures in the field of oral and maxillofacial surgery. PRP also shows promise in periodontal regenerative therapy and should continue to be studied by scientists and clinicians alike.
منابع مشابه
Comparative Study of Four Platelet-Rich Plasma Methods for Preparing Platelet Concentrates
Background: Platelet preparations have been used for a wide variety of clinical applications such as hemorrhage, tissue engineering and cellular therapy. Platelet concentrates can be prepared by the apheresis method or from the whole blood using the Buffy-coat or Platelet-rich plasma methods. The purpose of this study was to compare four variations of platelet-rich plasma method based on double...
متن کاملPlatelet Rich Plasma: Review of Literature
Objective: At present, growth factor-containing products such as enamel matrix derivatives, recombinant bone morphogenetic protein (rh-BMP), recombinant platelet derived growth factor and platelet rich plasma (PRP) have gained increasing attention. PRP is an autologous source of platelet growth factors used to enhance healing of soft and hard tissues. PRP has gained popularity due to its auto...
متن کاملPlatelet-rich plasma as filling material in open sinus lift surgery
Background Many biomaterials are used during the open sinus lift surgery, beneath the elevated scheniderian membrane and maxillary sinus bony floor but the search for Ideal material continues. Methods In the maxillary posterior atrophic ridges with the bone height less than four millimeters the open sinus lift surgery performed. The autologous Platelet-rich plasma (PRF) was used as the sol...
متن کاملMaxillary alveolar bone grafting: the role of Platelet-rich plasma (PRF)
Introduction: Gold standard for alveolar cleft bone grafting is autogenous bone. Advantage of adding the growth factors to the bone is established, so adding PRF to the autogenous bone may have beneficial effects. Methods: Platelet-rich plasma admixed with autogenous bone and as a biologic membrane over the bone grafted alveolar cleft was used. Results: Autogenous bone in all (four cases...
متن کاملClinical Results of Platelet-Rich Plasma for Partial Thickness Rotator Cuff Tears: A Case Series
Partial thickness rotator cuff tears (PTRCTs) are a common pathology among shoulder disorders in people over 50 years.Treatment of PTRCTs remains controversial. Most studies on the treatment of PTRCTs have explained surgical techniquesor outcomes; few studies have centralized on the conservative and new management of PTRCTs, like treatmentwith Platelet-rich plasma (PRP). These case series study...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Journal of the American Dental Association
دوره 133 10 شماره
صفحات -
تاریخ انتشار 2002